PRELIMINARY PROGRAM

16:00 - 16:30

A-0163 Spermatogonial Stem Cell-based therapies: from innovation to implementation
Ellen Goossens
Belgium

17:00 - 17:20

A-0024 Genetic Architecture of Penile Volume in the General Population
Gunnar P Kordes (1), Philipp Beeken (1), Lynn Ogoniak (2), Jan Ernsting (3)(4)(5) Nils Johannaber (1), Benjamin Risse (3)(4), Alexander S Busch (1)
(1) Department of General Pediatrics, University Hospital Münster, Germany; (2) Institute of Medical Informatics, University of Münster, Germany; (3) Institute for Geoinformatics, University of Münster, Germany; (4) Faculty of Mathematics and Computer Science, University of Münster, Germany; (5) Institute for Translational Psychiatry, University of Münster, Germany

17:20 - 17:40

A-0101 Diffusion-Generated Synthetic Testicular Ultrasound Images for AI Development in Male Infertility Assessment
Daniele Renda Livraghi (1)(2), Giorgia Spaggiari (1)(2)(3), Antonio R. M. Granata (1)(3), Carlotta Pozza (4), Marta Tenuta (4), Andrea M. Isidori (4), Manuela Simoni (1)(2), Nicola Morelli (5), Kevin Marchesini (5), Federico Bolelli (5), Costantino Grana (5), Daniele Santi (1)(2)(3)
(1) Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, 41126, Modena, Italy; (2) Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126, Modena, Italy; (3) Unit of Andrology and Sexual Medicine of the Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, 41126, Modena, Italy; (4) Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy; (5) Enzo Ferrari Department of Engineering, University of Modena and Reggio Emilia, 41125, Modena, Italy

17:40 - 18:00

A-0110 The remodeling of nuclear transport at the mitosis-to-meiosis transition is a crucial determinant for successful spermatogenesis
Joana Martins Almeida (1), Margot J. Wyrwoll (2), Antoni Riera-Escamilla (3), Inês Ferreira (1), Catarina Lopes (4), Laura Quintas (5), João Guimarães (5), Sabine Kliesch (6), Corinna Friedrich (7), Nuno Santos (4), Donald F. Conrad (3), Joris Veltman (2), Frank Tüttelmann (7), Paulo Navarro-Costa (1)
(1) EvoReproMed Lab, Lisbon School of Medicine, Lisbon, Portugal; (2) Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK; (3) Oregon Health & Science University, Oregon, USA; (4) Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal; (5) ERA Chair iSTARS, Lisbon School of Medicine, Lisbon, Portugal; (6) Department of Andrology, Centre of Reproductive Medicine and Andrology, University Hospital Münster, Münster, Germany; (7) Institute of Reproductive Genetics, Centre of Medical Genetics, University of Münster, Münster, Germany

08:00 - 08:30

A-0170 Practical interpretation of a WES report in diagnosing male infertility
Frank Tüttelmann
Germany

08:00 - 08:06

A-0275 Assessing gene expression and chromatin accessibility dynamics in the early prepubertal Sertoli cell population of the primate testis
Nadia Y Edelsztein (1), Stefan Schlatt (2), Alexander S Busch (1)
(1) Department of General Paediatrics, University of Münster, Münster, Germany; (2) Centre for Reproductive Medicine and Andrology, Münster, Germany

08:06 - 08:12

A-0042 Sexual Dysfunction in Male IBD Patients on Advanced Treatments: Insights into a Neglected Dimension of Quality of Life
Marilina Romeo (1), Cristina Bezzio (2)(3), Walter Vena (1)(2), Giulia Migliorisi (3), Andrea Dall'Oca (1)(2), Roberto Gabbiadini (3), Laura Loy (3), Giuseppe Privitera (2)(3), Antonio Carlo Bossi (1), Ferdinando D'Amico (4), Andrea Sansone (5), Alessandro Pizzocaro (2)(6), Alessandro Armuzzi (2)(3), Andrea Gerardo Lania (2)(6)
(1) Endocrinology and Diabetes Unit, Humanitas Gavazzeni, Bergamo, Italy; (2) Department of Biomedical Sciences, Humanitas University, Milan, Italy; (3) IBD Center, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy; (4) Department of Gastroenterology, IRCCS Ospedale San Raffaele, Milan, Italy; (5) Chair of Endocrinology and Sexual Medicine (ENDOSEX) Department of System Medicine, University of Rome Tor Vergata, Rome, Italy; (6) Endocrinology, Diabetology and Medical Andrology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy

08:12 - 08:18

A-0046 Human Sertoli-to-granulosa cell transdifferentiation caused by a somatic DMRT1 mutation evidenced by a testicular granulosa cell tumor case
Sofia Boeg Winge (1)(2), Terje Svingen (3), Niels Erik Skakkebaek (1)(2), Maria Rossing (4), Lise Barlebo Ahlborn (4), Birgitte Grønkær Toft (5)(6), Lise Aksglaede* (1)(2), Gedske Daugaard* (7)
(1) Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Denmark; (2) International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet; (3) National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark; (4) Department of Genomic Medicine, Copenhagen University Hospital - Rigshospitalet; (5) Department of Pathology, Copenhagen University Hospital - Rigshospitalet; (6) Department of Clinical Medicine, University of Copenhagen, Denmark (7) Department of Oncology, Copenhagen University Hospital - Rigshospitalet; *Shared last authors

08:18 - 08:24

A-0093 Luteinizing hormone (LH) and human choriogonadotropin (hCG) induce ligand-specific steroid secretion profile in the mouse Leydig tumor cell line 1 (mLTC1)
Clara Lazzaretti (1), Carmela Perri (1)(2), Flaminia Fanelli (3), Valentina Bissi (3), Giada Mercanile (1)(4), Samantha Sperduti (1)(5), Monica Lispi (6), Daniele Santi (1)(7), Manuela Simoni (1)(5)(7), Livio Casarini (1)(5)
(1) Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; (2) International PhD School in Clinical and Experimental Medicine (CEM) University of Modena and Reggio Emilia, Modena, Italy; (3) Endocrinology research group, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; (4) Department of Dermatology, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy; (5) Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy; (6) Global Medical Affairs Fertility, Research and Development, Merck Healthcare KGaA, Darmstadt, Germany; (7) Azienda Ospedaliero-Universitaria di Modena, Department of Medical Specialties, Modena, Italy

08:24 - 08:30

A-0148 Slower Pubertal Trajectory Based on Testicular Volume, but Not Tanner Genitalia Staging, Predicts Reproductive Outcomes and Relates with Sperm Epigenetic Markers in Young Adulthood
Vitalik Bezuglov (1)(2)*, Anna Ponomareva (1)*, Victoria Shtratnikova (1)(2), Vasily Ashapkin (1)(2), Alexander Suvorov (3), Oleg Sergeyev (1)(2)(4)
(1) Skolkovo Institute of Science and Technology, Moscow, Russia; (2) Lomonosov Moscow State University, Moscow, Russia; (3) University of Massachusetts, Amherst, USA; (4) Research Centre for Medical Genetics, Moscow, Russia

08:30 - 08:36

A-0057 Impairment of Male Reproductive Function After Isotretinoin Exposure
Fie Bendix (1)(2), Lærke Priskorn (1)(2), Niels Jørgensen (1)(2), Hanne Frederiksen (1)(2), Anne Jørgensen (1)(3), Lina Mørch (4), Hans Christian Ring (5), Anna Rosenmai (6), Terje Svingen (6), Anders Juul (1)(2)(7), Anders Rehfeld (1)(2)
(1) The Department of Growth and Reproduction, Rigshospitalet, Copenhagen University Hospital, Denmark; (2) Center for Research in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital, Denmark; (3) Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital, Herlev and Gentofte, Denmark; (4) Cancer and Medicine, Danish Cancer Institute - Danish Cancer Society, Copenhagen, Denmark; (5) Department of Dermatology, Zealand University Hospital, Roskilde, Denmark; (6) National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark; (7) Department of Clinical Medicine, University of Copenhagen, Denmark

08:36 - 08:42

A-0069 Stimulation of the Leydig cells androgenic response using LH receptor agonist as a potential therapy for hypogonadism in Klinefelter syndrome
Fariba Saadati, Reinhild Sandhowe-Klaverkamp, Nora Elena Büttner-Wobst, Joachim Wistuba
Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University of Muenster, Muenster, Germany

08:42 - 08:48

A-0100 Can Microlithiasis disrupt Testicular Immune Privilege? Analysis on 1,755 Infertile Men
Civilla Matteo, Tienforti Daniele, Spagnolo Luca, Pisanó Carlo, Cocci Elisa, Barbonetti Arcangelo
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

08:48 - 08:54

A-0226 Machine learning models may predict the presence of validated pathogenic/ likely pathogenic gene variants in men with non-obstructive azoospermia and micro-TESE failure
Mohamed Wael Ragab (1)(2), Haitham El-Hussieny (3), Hesham Hanafy (1)(2), Ali Mahran (4), Mohamed Arafa (1)(5)(6)
(1) Department of Andrology, Cairo University, Cairo, Egypt; (2) Dar Al-Nokhba IVF center, Cairo, Egypt; (3) Department of Mechatronics and Robotics Engineering, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt; (4) Department of Andrology, Venereology and Infertility Surgery, Assiut University, Assiut, Egypt; (5) Department of Urology, Hamad Medical Corporation, Doha, Qatar; (6) Department of Urology, Weill Cornell Medicine-Qatar, Doha, Qatar

08:54 - 09:00

A-0080 Exome and genome sequencing entering routine andrology practice – Estonian experience
Maris Laan (1), Kristjan Pomm (2)(3), Margus Punab (1)(2)(3)
(1) Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia, Estonia; (2) Andrology Clinic, Tartu University Hospital, Tartu, Estonia; (3) Institute of Clinical Medicine, University of Tartu, Tartu, Estonia

08:00 - 08:06

A-0206 Erectile dysfunction and lifestyle: independent role of sleep quality in a large real-world cohort
Davide Menafra (1), Cristina de Angelis (1), Francesco Garifalos (1), Nunzia Verde (1), Alessandro Mazzarella (1), Simona Ferazzoli (1), Eugenio Formisano (1), Vincenzo Frulio (1), Simone Rinaldi (1), Mariangela Piscopo (1), Tonia Romano (1), Annamaria Colao (1)(2), Rosario Pivonello (1)(2)
(1) Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia ed Andrologia - Unità di Andrologia e Medicina della Riproduzione, Sessualità e Affermazione di Genere - Università Federico II di Napoli, Naples, Italy; (2) Unesco Chair for Health Education and Sustainable Development, Federico II University, Naples, Italy

08:06 - 08:12

A-0236 Maternal serum concentrations of 4-hydroxychlorothalonil during pregnancy and the association with risk of testicular germ cell cancer in male offspring
Cecilie S. Uldbjerg (1)(2), Christian Lindh (3), David M. Kristensen (1)(2)(4), Youn-Hee Lim (5), Jørgen H. Petersen (1)(2)(6), Karina M. Sørensen (7), Panu Rantakokko (8), Brent A. Coull (9), Elvira V. Bräuner (1)(2), Russ Hauser (10), Niels E. Skakkebæk (1)(2)(11), Anders Juul (1)(2)(11), Lærke Priskorn (1)(2)
(1) Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, University of Copenhagen, Denmark; (2) International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; (3) Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden; (4) Roskilde University, Department of Science and Environment, Roskilde, Denmark; (5) Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; (6) Section of Biostatistics, Department of Public Health, University of Copenhagen, Denmark; (7) Danish National Biobank, Statens Serum Institut, Denmark; (8) Department of Public Health, Finnish Institute for Health and Welfare, 70701 Kuopio, Finland; (9) Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, USA; (10) Department of Environmental Health, T.H. Chan School of Public Health, Harvard University, USA; (11) Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

08:12 - 08:18

A-0242 Determinants of androgen abuse withdrawal symptoms: a cross-sectional study of community-dwelling men
Bonnie Grant (1), Joseph Kean (2), Nipun Lakshitha de Silva (1)(3), Rodrigo Aguilera (4), Oliver Quinton (1), Maha Gumssani (1), Paul Bassett (5), Waljit S. Dhillo (1), Anne Lingford-Hughes (6), Kim Wolff (4), Channa N. Jayasena (1)
(1) Section of Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; (2) BloodWorks Ltd, Bradford, UK; (3) Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defence University, Ratmalana, Sri Lanka; (4) Drug Control Centre, King’s Forensics, Faculty of Life Science and Medicine, King’s College London, London, UK; (5) Statsconsultancy Ltd, Bucks, UK; (6) Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK

08:18 - 08:24

A-0246 A Combined Collagenase and Density‑Gradient Method Boosts MicroTESE Outcomes in Non-Obstructive Azoospermia due to SCOS and Maturation Arrest
Marjan Sabbaghian (1), Elisabetta Piatti (2), Marina Bellavia (2), Fabrizio Castiglioni (2), Franco Nerva (2), Giacomo Gazzano (3), Germar-Michael Pinggera (4), Giovanni Maria Colpi (2)
(1) Dept. of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran; (2) Andrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland; (3) Pathology Unit, Istituto Auxologico Italiano IRCCS, Milano, Italy; (4) Dept. of Urology, Medical University Innsbruck, Innsbruck, Austria

08:24 - 08:30

A-0261 Global Prevalence of Klinefelter Syndrome in Prenatal Diagnosis: Higher Detection with NIPT Compared to Conventional Methods — A Systematic Review of Temporal Trends and Screening Modalities
Francesco Costantino (1)(2), Antonio Percesepe (3)(4), Riccardo Cuoghi Costantini (5), Maria Chiara Decaroli (1)(2), Sara De Vincentis (1)(2), Vincenzo Rochira (1)(2)
(1) Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; (2) Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy; (3) Department of Surgery and Medicine, University Hospital Parma, Italy; (4) UO Genetica Medica-University Hospital Parma, Italy; (5) Azienda Ospedaliero Universitaria of Modena, Unit of Statistical and Methodological Support to Clinical Research, Modena, Italy

08:30 - 08:36

A-0263 Mosaic loss of Y chromosome as a therapy-induced biomarker of accelerated aging in young oncological patients
Csilla Krausz (1), Chiara Abrardo (1), Viola Bonini (1), Giuseppe Defazio (1)(2), Fabiola Balestri (1), Daniel Moreno-Mendoza (3), Eduard Ruiz-Castañé (3), Antoni Riera-Escamilla (3)
(1) Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; (2) Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, Bari, Italy; (3) Department of Andrology, Fundació Puigvert, Instituto De Investigaciones Biomédicas Sant Pau (IIB-Sant Pau) Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain

08:36 - 08:42

A-0298 Problematic online pornography use and erectile dysfunction
Maurizio De Rocco Ponce (1), Francesc Maestre (2), Ricardo Contreras (1), Gabino Adalid (1), Josvany Sanchez Curbelo (1), Xavier López-i-Martin (3), Josep Castillo-Garayoa (4)
(1) Andrology Departament, Fundació Puigvert, Barcelona, Spain; (2) Psychology Departament, Fundació Puigvert, Barcelona, Spain; (3) Universidad Oberta de Catalunya, Barcelona, Spain; (4) FPCEE Blanquerna, Universitat Ramon Llull, Barcelona, Spain

08:42 - 08:48

A-0300 Cognitive Behavioral Sex Therapy for Patients with Peyronie's Disease: A Pilot Randomized Controlled Trial
Armin Soave (1), Carla Oltrogge (1), Martin Sangmeister (2), Johannes Moltrecht (1), Anika Buchholz (3), Amra Pepic (3), Andrea Salzbrunn (4), Margit Fisch (1), Timo O. Nieder (2)
(1) Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; (2) Institute for Sex Research, Sexual Medicine and Forensic Psychiatry, University Medical Center Ham-burg-Eppendorf, Hamburg, Germany; (3) Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Ham-burg, Germany; (4) Department of Andrology, Clinic for Dermatology and Venereology, University Medical Center Ham-burg-Eppendorf, Hamburg, Germany

08:48 - 08:54

A-0015 Role of Steroid Hormone-Binding Proteins on the Bioactivity of 11-Oxygenated Androgens
Jennifer Afrakoma Nyamaah (1), Astrid Claessens (1)(2), Nick Narinx (1)(3), Karl Storbeck (4), Pieter Vermeersch (3), Dirk Vanderschueren (1)(2), Frank Claessens (5), Leen Antonio (1)(2)
(1) Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium; (2) Department of Endocrinology, UZ Leuven, Leuven, Belgium; (3) Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium; (4) Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa; (5) Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium

08:54 - 09:00

A-0049 The bio-psycho-social correlates of male infertility
Anna Juhász (1)(2)(3), Balázs Matuszka (4), Zsolt Kopa (2)
(1) Semmelweis University, Doctoral College, Surgical Medicine Division, Budapest, Hungary; (2) Semmelweis University, Department of Urology, Andrology Centre, Budapest, Hungary; (3) Istenhegyi Géndiagnosztikai Centrum, Budapest, Hungary; (4) Pázmány Péter Catholic University, Faculty of Humanities and Social Sciences, Institute of Psychology, Budapest, Hungary

08:30 - 09:00

A-0164 The role of the couple in the Andrology field from sexual dysfunction to infertility
Linda Vignozzi
Italy

09:00 - 09:30

A-0165 The Metabolic impact of PDE5 inhibitors: 20 years of trials and Novel findings:
Andrea Isidori
Italy

09:30 - 10:00

A-0304 Unwrapping the sperm chromatin - new insights into protamine functions
Gina E. Merges
Germany

10:00 - 10:10

A-0035 Optimization of in vitro spermiogenesis in the mouse model
Eva Chemin, Laura Moutard, Magali Basille-Dugay, Valentin Rousseau, Ludovic Dumont, Nathalie Rives, Aurélie Feraille, Christine Rondanino
University of Rouen Normandy - Inserm U1239, Rouen, France

10:10 - 10:20

A-0047 Transgenerational effect of endocrine disruptors at subtoxic dosage on male reproductive function
Iva Sabovic (1), Andrea Di Nisio (2), Luca De Toni (1), Andjela Kovacevic (3), Stefano Gotti (4), Carlo Foresta (1), Alberto Ferlin (1)
(1) Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy; (2) Department of Health, Nutrition and Sport, Pegaso Telematic University, Napoli, Italy; (3) Institute of Pathology, Department of Developmental Pathology, Medical Faculty, University of Bonn, Bonn, Germany; (4) Neuroscience Institute Cavalieri Ottolenghi (NICO) University of Torino, Torino, Italy

10:20 - 10:30

A-0079 PWWP3B gene variants in male infertility: insights from human genetics, in vitro assays, and a mouse model
Leonie Herrmann (1), Shoham Kaufman (2), Juan Manuel Parturlanne (3), Assiel Rahimy (1), Sophie Adina Koser (1), Daniela Fietz (4), Jens Rosellen (5), Hans-Christian Schuppe (5), Sabine Kliesch (6), Nina Neuhaus (3), Nitzan Gonen (2), Frank Tüttelmann (1)
(1) Institute of Reproductive Genetics (IRG), Centre of Medical Genetics (CMG), University of Münster, Münster, Germany; (2) Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel; (3) Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology (CeRA), University Münster, Münster, Germany; (4) Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Giessen, Germany; (5) Clinic and Polyclinic for Urology, Pediatric Urology and Andrology, University Hospital Giessen, Giessen, Germany; (6) Department of Andrology, Centre of Reproductive Medicine and Andrology (CeRA), University Hospital Münster, Münster, Germany

10:30 - 10:40

A-0095 Sequencing of the entire X chromosome reveals coding and regulatory variants pointing to novel candidate NOA genes
Viola Bonini (1), Ginevra Farnetani (1), Chiara Abrardo (1), Matteo Vannucci (1), Eduard Ruiz-Castañé (2), Antoni Riera-Escamilla (2), Csilla Krausz (1)
(1) Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; (2) Department of Andrology, Fundació Puigvert, Instituto De Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain

10:40 - 10:50

A-0240 Transgender-derived testicular tissue as a model for developing anti-fibrotic strategies in Klinefelter syndrome
Emily Delgouffe (1), Kim Aicha Feryn (1), Frédéric Chalmel (2), Veerle Vloeberghs (3), Guy T'Sjoen (4), Herman Tournaye (1)(3), Ellen Goossens (1)
(1) Vrije Universiteit Brussel, Brussels, Belgium; (2) Université de Rennes, Rennes, France; (3) Universitair Ziekenhuis Brussel, Brussels, Belgium; (4) Universitair Ziekenhuis Gent, Ghent, Belgium

10:50 - 11:00

A-0285 Abnormal sperm protamination is linked to reduced Septin12 levels and impaired motility
Ondrej Sanovec (1)(2), Magdalena Tuslova (1), Ondrej Simonik (1), Katerina Komrskova (1)(3)
(1) Institute of Biotechnology of the Czech Academy of Sciences, Vestec, Czech Republic; (2) Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic; (3) Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic

09:30 - 09:42

A-0193 Priapism
Wai Gin (Don) Lee
UK

09:42 - 09:54

A-0194 Infection
Fulvio Colombo
Italy

09:54 - 10:06

A-0195 Corporal Fibrosis
Afonso Morgado
Portugal

10:06 - 10:18

A-0196 Peyronie’s disease
Agustín Fraile
Spain

10:00 - 10:20

A-0171 New insights into FSH receptor signalling
Livio Casarini
Italy

10:20 - 10:40

A-0172 Clinical effects of FSH in male patients with couple infertility
Hussein Kandil
UAE

10:40 - 10:50

A-0139 Deep Phenotyping of Male Infertility Improves the Response to FSH Treatment in Normogonadotropic Oligo-Asthenozoospermia
Giuseppe Grande (1), Andrea Graziani (1)(2), Alberto Scala (2), Nicola Caretta (1), Antonella Di Mambro (1), Andrea Garolla (1)(2), Alberto Ferlin (1)(2)
(1) University Hospital of Padua, Department of Medicine, Unit of Andrology and Reproductive Medicine, Padua, Italy; (2) University of Padua, Department of Medicine, Padua, Italy

10:50 - 11:00

A-0122 Intracytoplasmic Sperm Injection Outcomes in Men with High Sperm DNA Fragmentation: Testicular Versus Ejaculated Sperm
Ahmad Majzoub (1)(2), Ahmad Almalki (1)(3), Ahmed Alsaeedi (1), Kareim Khalafalla (1)(3), Khalid AlKubaisi (1)(3), Sami AlSaid (1)(2), Nadir Fadol (1), Mohamed Arafa (1)(2)(4), Haitham Elbardisi (1)(2)(3)
(1) Urology Department, Hamad Medical Corporation, Doha, Qatar; (2) Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; (3) Urology Department, Qatar University, Doha, Qatar; (4) Andrology Department, Cairo University, Doha, Qatar

10:20 - 10:40

A-0200 Debate - Pro
Giorgio Franco
Italy

10:40 - 11:00

A-0201 Debate - Contra
Sabine Kliesch
Germany

12:00 - 12:30

A-0166 Results from the large Nestorone + testosterone combination gel efficacy trial
Christina Wang
USA

14:00 - 14:20

A-0173 Total and free testosterone measurements in European laboratories
Nick Narinx
Belgium

14:20 - 14:40

A-0174 Variability in SHBG assays and SHBG gene polymorphisms and the effect on cFT
Bruno Lapauw
Belgium

14:40 - 14:50

A-0255 Novel sperm molecular biomarker for selecting spermatozoa with intact DNA
Mikel Albizuri (1)(3), Malen Zabala (3), Ainize Odriozola (1)(2)(3), Irune Calzado (1)(2), Manu Araolaza (1)(2), Iratxe Ajuria-Morentin (2)(4), Lorena Crisol (5), Maria Aranzazu Guembe (5), Roberto Matorras Weining (2)(6), Nerea Subirán (1)(2)(3)
(1) Department of Physiology, University of the Basque Country, Leioa, Bizkaia, Spain; (2) Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain; (3) MEPRO Medical Reproductive Solutions SL, Donostia-San Sebastián, España; (4) Galdakao-Usansolo Hospital, Galdakao, Bizkaia, Spain; (5) Donostia Hospital, Donostia-San Sebastian, Gipuzkoa, Spain; (6) Cruces Hospital, Galdakao, Bizkaia, Spain

14:50 - 15:00

A-0099 Testicular biopsy transcriptomics reveals molecular signatures predictive of negative sperm retrieval in non-obstructive azoospermia
Alexandra Kondic, Sofie Fagerström, Jonatan Axelsson, Angel Elenkov
(1) Lund University, Department of Translational Medicine; (2) Skåne University Hospital, Centre of Reproductive Medicine

14:00 - 14:07

A-0188 Management of bone health in the andrological outpatient clinic. Pathophysiology and diagnosis
Sara De Vincentis
Italy

14:07 - 14:14

A-0189 Management of bone health in the andrological outpatient clinic/Therapy. Pathophysiology and diagnosis
Karel David
Belgium

14:14 - 14:29

A-0190 Male Contraception
Cristina Meriggiola
Italy

14:29 - 14:44

A-0191 Testicular Biopsies in Adolescent and Adult Andrological Patients
Niels Joergensen
Denmark

14:00 - 14:20

A-0185 Update on ART outcomes
Edgar Mocanu
Ireland

14:20 - 14:40

A-0186 Impact of male factor on female fertility
Dimitrios Goulis
Greece

14:40 - 15:00

A-0187 Is there a still room for Art in ART?
Luca Gianaroli
Italy

15:00 - 15:30

A-0167 Fetal and Adult Leydig cells: A tale of their origin and fate
Jacques J. Tremblay
Canada

16:00 - 16:20

A-0175 Obesity and Male Fertility: Looking Beyond Semen Analysis
Andrea Salonia
Italy

16:20 - 16:30

A-0106 Testicular function in young men and risk of cardiometabolic disease up to 20 years later – a register-based follow-up study of more than 5000 men
Laura Smidt Hansen (1)(2), Astrid Linnea Beck (1)(2), Julie Abildgaard (1)(2)(3), Anders Juul (1)(2)(4), Jørgen Holm Petersen (1)(2)(5), Niels Jørgensen (1)(2), Lærke Priskorn (1)(2)
(1) Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark; (2) International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC) Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark; (3) The Centre for Physical Activity research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; (4) Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; (5) Section of Biostatistics, Department of Public Health, University of Copenhagen, DK-1353 Copenhagen, Denmark

16:30 - 16:40

A-0136 Multiparametric profiling of male infertility: genomic and ultrastructural sperm damage in relation to oxidative stress, age and body mass index
Girolamo Francesca(1), Saracini Giada (1), Ponchia Rosetta (1), Boschi Letizia (1), Barhoumi Mayssa(1), Luongo Francesca Paola(2), Governini Laura (1), Morgante Giuseppe (1), Alice Luddi(1), Paola Piomboni(1)\r\n\r\n
(1) Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena,Italy.\r\n(2) Departmental Faculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, Italy

16:00 - 16:20

A-0176 PRO
Angelo Cignarelli
Italy

16:20 - 16:40

A-0177 CON
Dimitrios Goulis
Greece

16:40 - 16:50

A-0297 Beyond weight loss: tirzepatide directly reprograms the testicular transcriptome in male mice with obesity, diabetes and hypogonadism through a caloric restriction-independent mechanism
Valentina Annamaria Genchi (1), Celeste Lauriola (1), Nicola Marrano (1), Giuseppina Biondi (1), Annalisa Natalicchio (1), Sebastio Perrini (2), Luigi Laviola (1), Francesco Giorgino (1), Angelo Cignarelli (1)
(1) Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy; (2) Section of Endocrinology, Department of Medicine and Surgery, LUM University, Casamassima, Bari, Italy

16:50 - 17:00

A-0241 Online information and testosterone therapy: A global multilingual content analysis
Bonnie Grant (1), Nipun Lakshitha de Silva (1)(2), Maha Gumssani (1), Oliver Quinton (1), Faysal Kayali (3), Isuru Lakmith Gamage (4), Waljit S. Dhillo (1), Mathis Grossmann (4)(5), Channa N. Jayasena (1)
(1) Section of Investigative Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK; (2) Department of Clinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defence University, Ratmalana 10370, Sri Lanka; (3) Imperial College Healthcare NHS Trust, The Bays, London W2 1NY, UK; (4) Department of Endocrinology, Austin Health, Heidelberg, Victoria 3084, Australia; (5) Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia

16:00 - 16:12

A-0197 News in medical therapy
Paolo Capogrosso
Italy

16:12 - 16:24

A-0198 Low-intensity extracorporeal shock wave therapy
Fotios Dimitriadis
Greece

16:24 - 16:36

A-0199 PRP
Eduard Ruiz Casane
Spain

17:00 - 17:20

A-0178 piRNA Dysregulation: Small RNAs, Big Impact on Male Fertility
Kristian Almstrup
Denmark

17:20 - 17:40

A-0179 Couple-Based Genetic Screening: Matching Carriers to Uncover Recessive Risks in Male Infertility
Antonio Capalbo
Italy

17:40 - 17:50

A-0215 Association of Spermatozoal RNA Expression with Fertilization Outcomes in ART
Thomas Greither, Lina Albrecht, Diana Handke, Ivan Hoffmann, Hermann M. Behre
Center for Reproductive Medicine and Andrology, University Medicine Halle, Halle (Saale), Germany

17:50 - 18:00

A-0022 Identification of whole exome sequencing derived spermatogenic gene associated copy number variants in idiopathic hypospermatogenesis patients
Nisha Sharma (1), Ashutosh Halder (1), Seema Kaushal (2), Manoj Kumar (3), Manish Jain (1)
(1) Department of Reproductive Biology, All India Institute of Medical Sciences New Delhi, India; (2) Department of Pathology, All India Institute of Medical Sciences New Delhi, India; (3) Department of Urology, All India Institute of Medical Sciences New Delhi, India

17:00 - 17:06

A-0222 Is 'Living Apart Together' a real advantage for patients consulting for sexual dysfunction? A cohort study
Clotilde Sparano (1), Giovanni Corona (2), Giulia Rastrelli (3), Linda Vignozzi (3), Daniele Vignoli (4), Mario Maggi (1)
(1) Endocrinology Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; (2) Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy; (3) Andrology, Women's Endocrinology and Gender Incongruence Unit, 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; (4) Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy;

17:06 - 17:12

A-0262 Sex steroids measurement by mass spectrometry in hypogonadal men in a real-world setting: serum estradiol (E2) and E2 to Total Testosterone (TT) ratio do not differ between patients with Klinefelter Syndrome (KS) and non-KS hypogonadism
Sara Cerrato (1), Daniele Renda Livraghi (1), Francesco Costantino (1)(3), Filippo Vignali (1), Giulia Canu (2), Maria Cristina De Santis (2), Laura Roli (2), Tommaso Fasano (2), Sara De Vincentis (1)(3), Vincenzo Rochira (1)(3)
(1) Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; (2) Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Modena, Italy; (3) Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Ospedale Civile di Baggiovara, Modena, Italy

17:12 - 17:18

A-0271 Measuring the prevalence of gender identities according to XYGO in a non-clinical sample of Italian people
Andrea Sansone (1), Elena Colonnello (1), Tommaso B Jannini (2), Emmanuele A. Jannini (3)
(1) Section of Endocrinology and Medical Sexology (ENDOSEX) Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; (2) Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy; (3) Chair of Endocrinology and Medical Sexology (ENDOSEX) Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

17:18 - 17:24

A-0030 Concentration Matters: Prevalence Of Genetic Disorders Is Associated With The Severity of Seminal Abnormalities
Jose Ignacio Vinay (1) (2) (3), Ricardo Sobell (2), Mauricio Andriola (2), Joaquin Sanhueza (2)
(1) Uros Associats Teknon, Barcelona, Spain; (2) Faculty of Medicine, University of Chile, Santiago, Chile; (3) Shady Grove Fertility, Santiago, Chile

17:24 - 17:30

A-0070 A shared language of life: conserved essential proteins underlying mammalian fertilisation
Emilie Zeine (1), Laurence Stouvenel (1), Marine Foritano (1), Ahmed Ziyyat (1)(2)
(1) Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France; (2) Service d'Histologie, d'Embryologie, Biologie de la reproduction, AP-HP, Hôpital Cochin, Paris, France

17:30 - 17:36

A-0278 Are Large Language Models Ready for Clinical Explainability in Andrology? Insights from a Clinician-Based Evaluation
Moreno La Quatra (1), Francesco Pallotti (2), Giorgia Spaggiari (3), Daniele Santi (3), Nicole Dalia Cilia (1)
(1) University of Enna "Kore", Department of Engineering and Architecture, Enna, Italy; (2) University of Enna "Kore", Department of Medicine and Surgery, Enna, Italy; (3) University of Modena and Reggio Emilia, Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy

17:36 - 17:42

A-0007 Spermatic cord block as a treatment modality in chronic scrotal pain: a tertiary referral center study
Massimiliano Raffo, Josvany Rene Sanchez Curbelo, Maurizio De Rocco Ponce, Luis Malca Caballero, Jose Antonio Arrus Soldi, Ricardo Contreras Garcia, Sebastian Dumas, Gabi Adalid, Eduard Ruiz-Castane, Doron Vantman Luft
Fundacio Puigvert, Barcelona, Spain

17:42 - 17:48

A-0086 Impact of chemotherapy regimens on spermatogonia subpopulations and somatic cells in (pre)pubertal boys’ testicular tissue prior to cryopreservation
Valentin Rousseau (1), Nathalie Rives (1)(2), Manon Charles (1), Magali Basille-Dugay (1), Caroline Neusius (2), François Fraissinet (1)(3), Eva Chemin (1), Marion Dufour (1)(2), Hugo Dupuis (1)(2), Christine Rondanino (1), Aurélie Feraille (1)(2), Ludovic Dumont (1)
(1) Univ Rouen Normandie, INSERM, NORDIC UMR 1239 – Team Adrenal and Gonadal Pathophysiology (AGoPath), Rouen, France; (2) Rouen University Hospital, Department of Biology of Reproduction-CECOS laboratory, Rouen, France; (3) Rouen University Hospital, Department of General Biochemistry, Rouen, France

17:48 - 17:54

A-0112 Molecular Characterization of a Microtubule-Associated Protein in Human Sperm and Its Association with Asthenozoospermia
Adli Othamne (1), Ezzahra Rachid (3), Kbirou Adil (1)(2), Aboutaieb Rachid (1)(2)
(1) Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco; (2) Department of Urology, Ibn Rochd University Hospital Center, Casablanca, Morocco; (3) Science & Engineering of Biomedicals, Biophysics and Health Laboratory, Higher Institute of Health Sciences, Hassan First University of Settat, Morocco

17:54 - 18:00

A-0118 Novel compound heterozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella
Peng Ge, Jianpeng Zheng, Junqi Wang
Department of Urology, The Affiliated Hospital of Xuzhou Medical University, 221002 Xuzhou, Jiangsu, China

17:00 - 17:12

A-0202 Hormonal treatment of transgender and non-binary persons
Justine Defreyne
Belgium

17:12 - 17:24

A-0203 Attitudes of transgender and gender-diverse adolescents and their parents on parenthood and fertility preservation before starting hormone therapy
Tessa Stolk
The Netherlands

17:24 - 17:36

A-0204 Surgical management of transgender and non-binary persons
Andrea Cocci
Italy

17:36 - 17:48

A-0205 Law, policy and ethics of transgender and non-binary persons
Angelo Schillaci
UK

08:00 - 08:06

A-0277 The effect of treatment with aromatase inhibitors on sexual desire in men: a meta-analysis
Giovanni Corona (1), Giulia Rastrelli (2), Clotilde Sparano (3), Linda Vignozzi (2), Alessandra Sforza (4), Mario Maggi (3)
(1) Endocrinology and Metabolic Diseases, AUSL Romagna, Forli'-Cesena, Italy; (2) Andrology and Gender Endocrinology Unit, Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; (3) Endocrinology Unit, Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; (4) Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy

08:06 - 08:12

A-0235 Early Life Stress Reprograms Hippo Signaling in the Testis Despite Increased Body Growth: Converging Evidence from Developmental and Mechanistic Models
İrem İnanç (1), Onur Bender (2), Ekin Baysal (3), Arzu Atalay (2), Esra Erdemli (1)
(1) Ankara University, Faculty of Medicine, Department of Histology and Embryology, Ankara, Turkey; (2) Ankara University, Biotechnology Institute, Ankara, Turkey; (3) İstanbul University, Faculty of Medicine, Department of Histology and Embryology, İstanbul, Turkey

08:12 - 08:18

A-0076 Differential proteomic maturity in sperm cells subjected to selection procedures in couples with unexplained infertility
Marina Leiva (1), Meritxell Jodar (1)(2), Maria Corredor (1), Mar Domingo (1), Marta Guimerà (3), Aina Borràs (3)(4), Dolors Manau (3)(4), Juan Manuel Corral (5), Judit Castillo (1), Rafael Oliva (1)(2)
(1) Molecular Biology of Reproduction and Development Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Fundació de Recerca Clínic Barcelona (FRCB), Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain; (2) Biochemistry and Molecular Genetics Service, Hospital Clínic Barcelona, Barcelona, Spain; (3) Gynecology, Obstetrics and Neonatology Clinical Institute (ICGON), Hospital Clínic Barcelona, Barcelona, Spain; (4) Gynecology, Human Reproduction and Women´s Health Research Group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; (5) Urology Service, Andrology Unit, Nephrology and Urology Clinical Institute (ICNU), Hospital Clínic Barcelona, Barcelona, Spain

08:18 - 08:24

A-0126 Anti-Müllerian hormone and surgical sperm retrieval in nonobstructive azoospermia: an aetiology-specific systematic review and meta-analysis
Carlo Pisanò, Daniele Tienforti, Claudio Capuano, Elisa Cocci, Luca Spagnolo, Arcangelo Barbonetti
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

08:24 - 08:30

A-0130 Human testicular germ cell tumours: evolving links between immune landscape and specialized vascularisation
Nina Ihring (1), Leonie Amann (1)(2), Pia Holtkamp (1), Miriam Figura (1), Ayele T. Tsedeke (1), Jens Rosellen (2), Federico Lanza (2), Monika Fijak (3)(4), Hiba Hasan (3), Daniela Fietz (1)(4), Hans-Christian Schuppe (2)(4)
(1) Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Germany; (2) Dept. of Urology, Paediatric Urology and Andrology, Justus Liebig University Giessen, Germany; (3) Institute for Anatomy and Cell Biology, Justus Liebig University Giessen, Germany; (4) Hessian Centre for Reproductive Medicine (HZRM) Justus Liebig University Giessen, Germany

08:30 - 08:36

A-0256 Proteomic profiling reveals energy metabolism disruptions in unexplained male infertility
Nerea Subirán (1)(2), Itziar Urizar-Arenaza (1)(2), Beatriz Navarro Santos (3), Manu Araolaza (1)(2)
(1) Department of Physiology, University of the Basque Country, Leioa, Bizkaia, Spain; (2) Biocruces-Bizkaia Health Research Institute, Barakaldo, Spain; (3) Quirón Bilbao, Assisted Reproductive Unit, Bilbao, Spain

08:36 - 08:42

A-0098 Beyond biology: Social determinants shaping male sexual health and andrology care pathways in Morocco
Khadija Hidous (1), Rachid Aboutaieb (1)(2), Houssine Boufettal (1)(2)
(1) Laboratory of Sexual and Reproductive Health, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Casablanca, Morocco; (2) Urology Department, Ibn Rochd Hospital, Casablanca, Morocco

08:42 - 08:48

A-0109 Genotypic Distribution of High-Risk Human Papillomavirus and Its Association with Sexually Transmitted Infection Coinfections in Men Attending a Sexual Health Center in Lima, Peru
Gustavo A. Grandez-Castillo (1), Olenka Farfan-Zapata (1), Guido Bendezu-Quispe (2), J. Antonio Grandez-Urbina (1)
(1) Insalud Research, Lima, Peru; (2) Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru

08:48 - 08:54

A-0119 Does Sperm Source Matter in Cryptozoospermia? A Comparison of Testicular and Ejaculated Sperm for ICSI
Mohamed Arafa (1)(2)(3), Kareim Khalafalla (1)(4), Nadir Fadol (1), Ahmad Almalki (1)(4), Sami AlSaid (1), Khalid Alkubaisi (1), Ahmed AlSaeedi (1), Haitham Elbardisi (1)(2)(4), Ahmad Majzoub (1)(2)
(1) Urology Department, Hamad Medical Corporation, Doha, Qatar; (2) Urology Department, Weill Cornell Medicine-Qatar, Doha, Qatar; (3) Andrology Department, Cairo University, Doha, Qatar; (4) Urology Department, Qatar University, Doha, Qatar

08:54 - 09:00

A-0210 TRANSCEND-XR: Improving knowledge of late treatment effects among adolescent and young adult testicular cancer survivors
Davor Ježek (1), Maria O’Malley (2), Josephine Hegarty (2), Ismail Toygar (2), Maria Inês Clara (2), Jack P. Gleeson (3)(4), David Murphy (5), Sheena McHugh (6), Frances Shiely (6)(7), Aileen Murphy (8), Ann Kirby (8), Ida J. Korfage (9), Sophie Terhaard (9), Agnes van der Heide (9), Aisha Hussain (10), Matias Katajavaara Seidler (10), Lynda Corrigan (11), Patrice Kearney Sheehan (11), Daniele Raggi (12), Alison Reid (12), Michal Chovanec (13)(14), Patrizia Gianntempo (15), Jourik A. Gietema (16), Justine Fleur van der Feen (17), Francisco Lupiáñez-Villanueva (17), Ana Roca-Umbert (17), Joanne Reid (18), Paulo Alves (19)(20), Joana Soares (21), Karen Galvin (21), Michal Kubo (22), Adeline Salasc (23), Anna Patrikidou (24), Mohamad M. Saab (2)
(1) School of Medicine, University of Zagreb, Centre of Excellence for Reproductive and Regenerative Medicine, Zagreb, Croatia; (2) Catherine McCauley School of Nursing and Midwifery, University College Cork, Cork, Ireland; (3) Cancer Research @UCC, College of Medicine and Health, University College Cork, Cork, Ireland; (4) Cork University Hospital/University College Cork Cancer Centre, Cork University Hospital, Cork, Ireland; (5) School of Computer Science and Information Technology, University College Cork, Cork, Ireland; (6) School of Public Health, University College Cork, Cork, Ireland; (7) Health Research Board Clinical Research Facility, University College Cork, Cork, Ireland; (8) Department of Economics, Cork University Business School, University College Cork, Cork Ireland; (9) Erasmus MC, University Medical Center Rotterdam, Department of Public Health, Rotterdam, the Netherlands; (10) Khora, Copenhagen, Denmark; (11) Tallaght University Hospital, Dublin, Ireland; (13) 2nd Department of Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava, Slovakia; (14) Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia; (15) Fondazione Irccs Istituto Nazionale Dei Tumori, Milan, Italy; (16) Academisch Ziekenhuis Groningen, Groningen, the Netherlands; (17) PredictBy Research and Consulting, Barcelona, Spain; (18) The School of Nursing and Midwifery, Queen’s University Belfast, United Kingdom; (19) Center for Interdisciplinary Research in Health, Faculty of Health Sciences and Nursing, Catholic University of Portugal, Porto, Portugal; (20) School of Nursing, Catholic University of Portugal, Porto, Portugal; (21) FundtoInnovate Limited, Cork, Ireland; (22) Association of European Cancer Leagues, Brussels, Belgium; (23) Gustave Roussy, Villejuif, France; (24) Genito-urinary Oncology Team, Department of Medical Oncology and Drug Development Department, Gustave Roussy, France

08:00 - 08:06

A-0074 Testicular ultrasound inhomogeneity: clinical, seminal, hormonal and ultrasound correlates
Francesco Lotti (1)(2), Benedetta Batisti (1)(2), Michele Bertolotto (3)
(1) Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy; (2) Andrology and Gender Endocrinology Unit, University Hospital Careggi (AOUC), Florence, Italy; (3) Department of Radiology, University of Trieste, Ospedale di Cattinara, Trieste, Italy

08:06 - 08:12

A-0025 Erectile dysfunction and physical comorbidities in young men, a population-based cohort study
Anastasios Fylaktos (1)(2), Hans Järnbert-Pettersson (3), Mats Holmberg (3)(4), Jussi Jokinen (5)(6), Cecilia Ekéus (1)
(1) Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden; (2) ANOVA, Andrology, Sexual medicine, Trans medicine, Karolinska University Hospital, Stockholm, Sweden; (3) Department of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden; (4) Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden; (5) Department of Clinical Sciences, Psychiatry, Umeå University, Sweden; (6) Department of Clinical Neuroscience, Karolinska Institute, Sweden

08:12 - 08:18

A-0217 Super-resolution microvascular ultrasound is a novel and highly sensitive testicular functional imaging modality when tested in men with testicular dysfunction
Nikoleta Papanikolaou (1), Jipeng Yan (2), Biao Huang (2), Rhianna Davies (1), Cara Go (1), Waljit S. Dhillo (1), Suks Minhas (3), Adrian KP Lim (4), Meng-Xing Tang (2), Channa N Jayasena (1)
(1) Division of Diabetes, Endocrinology and Metabolism, Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK; (2) Department of Bioengineering, Imperial College London, London, UK; (3) Department of Urology, Charing Cross Hospital, London, UK; (4) Department of Imaging, Imperial College London and Healthcare NHS Trust, Charing Cross Hospital Campus, London, UK

08:18 - 08:24

A-0068 Seminal plasma HSPA2 as a non-invasive biomarker to distinguish Sertoli cell-only syndrome from mixed testicular atrophy in non-obstructive azoospermia
Raouda Sgaier (1), Hans-Christian Schuppe (2, 3), Adrian Pilatz (2), Jens Rosellen (2), Thorsten Diemer (2), Daniela Fietz (1, 3)
(1) Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University Giessen, Giessen, Germany; (2) Clinic and Polyclinic for Urology, Pediatric Urology and Andrology, University Hospital Giessen, Giessen, Germany; (3) Hessian Centre for Reproductive Medicine (HZRM), Justus Liebig University Giessen, Giessen, Germany

08:24 - 08:30

A-0089 High glucose supplementation aggravates experimental autoimmune epididymo-orchitis via localized Th17 skewing in the male reproductive tract
Jin-Chuan Liu(1)(2), Qun-Xiong Zeng(2), Fu Shi(1), Jiangxia Shi(1), Minmin Lyu(1), Yu Li(1), Yong-Gang Duan(1)
(1) Shenzhen Key Laboratory of Fertility Regulation, Center of Assisted Reproduction and Embryology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China; (2) Department of Obstetrics and Gynecology, the University of Hong Kong, Pokfulam Road, Hong Kong, China;

08:30 - 08:36

A-0279 Comparison of Functional and Anatomical Outcomes of Grafting and Combined (Graft and Tunical Shortening) Techniques in the Surgical Treatment of Peyronie\'s Disease
M. Firat Ozervarli, Fatih Ozdemir, Mert Emre Erden, Serhat Aksoy, Kaan Kutay Baser, Murat Dursun, Mazhar Ortaç, Ateş Kadıoglu
Istanbul University Istanbul Faculty of Medicine, Department of Urology, Istanbul, Turkey

08:36 - 08:42

A-0107 Global prevalence of recreational use of phosphodiesterase type 5 inhibitors: a systematic review and meta-analysis
Luca Spagnolo, Daniele Tienforti, Carlo Pisanò, Elisa Cocci, Matteo Civilla, Arcangelo Barbonetti
Andrology Unit, Hospital S. Salvatore, Department of Medical, Health, Life and Ambiental Sciences, University of L'Aquila, L'Aquila, Italy

08:42 - 08:48

A-0132 Dietary associations with sperm DNA fragmentation in men from infertile couples: Swedish RUBIC data
Viktor Svensson (1)(2), Aleksander Giwercman (1)(3), Henriette Svarre Nielsen (4), Jonatan Axelsson (1)(3)
(1) Reproductive Medicine Centre, Skåne University Hospital Malmö, Sweden; (2) Faculty of Medicine, Lund University, Sweden; (3) Reproductive Medicine, Department of Translational Medicine, Lund University, Sweden; (4) Department of Clinical Medicine, Obstetrics and Gynaecology, University of Copenhagen, Denmark

08:48 - 08:54

A-0154 Performance of an AI real-time detection model compared with computer-aided sperm analysis for sperm concentration
Trine B. Haugen (1), Pål A. H. Bentsen (1), Mario Iliceto (2), Eldri U. Due (1), Mette H. Stensen (2), David Mortimer (3), Vajira Thambawita (1)(4), Jorunn M. Andersen (1)
(1) Department of Life Sciences and Health, Oslo Metropolitan University, Oslo, Norway; (2) Volvat Spiren Oslo, Oslo, Norway; (3) Oozoa Biomedical, West Vancouver, BC, Canada; (4) Simula Metropolitan Center for Digital Engineering, Oslo, Norway

08:54 - 09:00

A-0143 Semen quality in transgender individuals seeking fertility preservation
Maurizio De Rocco Ponce (1), Eden Troka (2), Massimiliano Raffo (3)(4), Luis Miguel Malca Caballero (1), Alberto Ferlin (2), Andrea Salonia (3), Eduard Ruiz Castañé (1), Alberto Scala (2), Andrea Garolla (2)
(1) Fundación Puigvert, Andrology Department, Universitat Autònoma de Barcelona, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau) Barcelona, Spain; (2) Unit of Andrology and Reproductive Medicine, Department of Medicine (DIMED) University of Padua, Padua, Italy; (3) Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy; (4) University Vita-Salute San Raffaele, Milan, Italy

09:00 - 09:30

A-0192 Seminal fluid effects on uterine receptivity to embryo implantation: transcriptomic strategies to define molecular mechanisms
Sarah Robertson
Australia

09:30 - 10:00

A-0169 Are We Propagating Infertility Through IVF? Genetic Insights into HerITbility
Csilla Krausz
Italy

10:30 - 10:50

A-0180 Androgen deprivation and body composition changes
Andrea Berruti
Italy

10:50 - 11:10

A-0303 Beyond androgen suppression: estrogen deprivation effects in prostate cancer
Channa Jayasena
UK

11:10 - 11:20

A-0045 Longitudinal changes in reproductive hormones prior to clinical diagnosis of a testicular germ cell tumour
Nina Mørup (1)(2), Trine Holm Johannsen (1)(2)(3), Gedske Daugaard (4), Hanne Frederiksen (1)(2), Jørgen Holm Petersen (1)(2)(5), Michael Schwinn (6), Mette Skou Bentsen (6), Jakob T Bay (7), Henrik Ullum (8), Bertram Dalskov Kjerulff (9)(10), Kathrine Agergård Kaspersen (10), Christian Erikstrup (9)(10), Erik Sørensen (6), Sisse Rye Ostrowski (6)(11), Ole Birger Pedersen (7)(11), Kristian Almstrup (1)(2)(12), and Anders Juul (1)(2)(11)
(1) Department of Growth and Reproduction, Copenhagen University Hospital – Rigshospitalet, Denmark; (2) The International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, Copenhagen, Denmark; (3) Department of Clinical Biochemistry, Copenhagen University Hospital – Rigshospitalet, Denmark; (4) Department of Oncology, Copenhagen University Hospital – Rigshospitalet, Denmark; (5) Section of Biostatistics, University of Copenhagen, Denmark; (6) Department of Clinical Immunology, Copenhagen University Hospital – Rigshospitalet, Denmark; (7) Department of Clinical Immunology, Zealand University Hospital – Køge, Denmark; (8) Statens Serum Institut, Copenhagen, Denmark; (9) Department of Clinical Medicine, Aarhus University, Denmark; (10) Department of Clinical Immunology, Aarhus University Hospital, Denmark; (11) Department of Clinical Medicine, University of Copenhagen, Denmark; (12) Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark

11:20 - 11:30

A-0142 A Stepwise Imaging Framework for Testicular Lesions: when to observe, when to preserve, when to operate. Insights from a 20-Year Single-Center Experience
Marta Tenuta (1), Francesco Carlomagno (1), Franz Sesti (1), Francesco Angelini (1), Giulia Pellegrini (1), Daniele Apostoli (1), Lucia Manganaro (2), Giorgio Franco (3), Gabriele Savarese (3), Fabio Massimo Magliocca (2), Daniele Gianfrilli (1), Andrea Isidori (1)*, Carlotta Pozza (1)*
(1) Department of Experimental Medicine, Sapienza University, Rome, Italy; (2) Department of Radiological, Oncological and Pathological Sciences, Sapienza University, Rome, Italy; (3) Department of Maternal and Child Health and Urological Sciences, Sapienza University, Rome, Italy

10:30 - 10:50

A-0181 Genotyping, sperm handling, LAISS, embryo quality and ICSI outcome
Kaylee Holleman
The Netherlands

10:50 - 11:00

A-0096 Investigating the interaction between Perinuclear theca and GARIN proteins in sperm development and male fertility in mice
Andjela Kovacevic, Kathrin Burckhardt, Joana Gerstenberg, Simon Schneider, Gina E. Merges, Hubert Schorle
University of Bonn, University Hospital Bonn, Institute of Pathology, Department of Developmental Pathology

11:00 - 11:10

A-0071 Human stem cell-derived Sertoli-like cells recapitulate early Sertoli cell transcriptomic signatures
Mathangi Lakshmipathi (1)(2), Saskia K. M. van Daalen (1)(2), Cindy M. de Winter- Korver (1)(2), Ans M. M. van Pelt (1)(2), Geert Hamer (1)(2), Callista L. Mulder (1)(2)
(1) Reproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands; (2) Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands

10:30 - 10:44

A-0231 Region-Specific Macrophage – Epithelial Crosstalk Shapes Epididymal Homeostasis
Tiziana Grimaldini (1)*, Julia König (2)*, Vishnu Kumar (3), Marek Bartkuhn (3), Sudhanshu Bhushan (1), Denise Messerer (4), Christian Schulz (5), Christiane Pleuger (1), Andreas Schlitzer (2)*, Andreas Meinhardt (1)*
(1) Institute of Anatomy and Cell Biology, Justus-Liebig-University of Giessen, Giessen, Germany; (2) Life & Medical Sciences, Biology of Inflammation, University of Bonn, Bonn, Germany; (3) Biomedical Informatics and Systems Medicine Science Unit for Basic and Clinical Medicine, Justus-Liebig University of Giessen, Giessen, Germany; (4) Medical Clinic and Polyclinic, Ludwig-Maximilians University Munich, Munich, Germany; (5) Institute for Innate Immunoscience, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

10:44 - 10:58

A-0232 Urinary metabolites of selected non-persistent endocrine-disrupting chemicals and sperm DNA fragmentation in young men from the general population
Renata Walczak-Jedrzejowska (1) , Joanna Jurewicz (2), Wojciech Hanke(3), Bartosz Wielgomas (4), Katarzyna Marchlewska (1), Jolanta Slowikowska-Hilczer (1)
(1) Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland; (2) Department of Chemical Safety, Nofer Institute of Occupational Medicine, Lodz, Poland; (3) Department of Occupational Diseases and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland; (4) Department of Toxicology, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland

10:58 - 11:12

A-0233 Artificial intelligence improves prediction of sperm retrieval success in non-obstructive azoospermia
Zsolt Kopa (1), József Bokor (2), Anett Szabó (1)
(1) Semmelweis University, Budapest, Hungary; (2) MTA SZTAKI, Budapest, Hungary

11:12 - 11:26

A-0013 Sub-Gluteal Ligation of the Internal Pudendal Vein for Management of Veno-Occlusive Erectile Dysfunction (Shaeer's Vein Ligation–I): The Cadaveric Study
Osama Shaeer (1)(2), Ehab A. A. El-Shaarawy (3), Hossam Y. Emam (3), Islam Elsisi (1), Eslam Sokar (1), Kamal Shaeer (1)
(1) Department of Andrology, Kasr El Aini Faculty of Medicine, Cairo University, Egypt; (2) The Middle East Society for Sexual Medicine; (3) Department of Anatomy and Embryology, Kasr El Aini Faculty of Medicine, Cairo University, Egypt

11:30 - 11:50

A-0182 PRO
Giulia Rastrelli
Italy

11:50 - 12:10

A-0183 CON
Michael Zitzmann
Germany

12:10 - 12:20

A-0032 Hypercortisolism and Male Hypogonadism: what is the role of Mild Autonomous Cortisol Secretion
Alessandro Ciarloni, Silvia Rossi, Michele Perrone, Nicola Ambo, Valentina Di Giacomi, Carlo Mazza, Marianna Martino, Gilberta Giacchetti, Gianmaria Salvio, Giancarlo Balercia
Clinica di Endocrinologia e Malattie del Metabolismo, Dipartimento di Scienze Cliniche e Molecolari, Ancona, Italy

12:20 - 12:30

A-0229 Comparative study between the effects of weight loss by Sleeve gastrectomy surgery versus liraglutide on male fertility
Mohamed Hassan Ali Fahmy (3), Mohamed Abdul Moneim Amin El Masry (3), Mina Saad (1)(2), Ehab Fathy Ahmed (3), Mohamed Mahmoud Saleh (3), Mohamed Wael Ragab (1)(2)
(1) Department of Andrology, Cairo University, Cairo, Egypt; (2) Dar Al-Nokhba IVF center, Cairo, Egypt; (3) Department of General and laparoscopic surgery, Cairo University, Cairo, Egypt

11:30 - 11:50

A-0184 ED as a symptom of psychiatric disease
Cobi Reisman
The Netherlands

11:50 - 12:10

A-0211 ED as a symptom of other sexual dysfunctions
Walter Vena
Italy

12:10 - 12:20

A-0043 Prolonged-release Sildenafil in erectile dysfunction: a randomized placebo-controlled comparison with a standard Sildenafil
Andrey Morozov (1), Svetlana Bogatova (2), Valeriia Patrikeeva (2), Leonid Spivak (1)
(1) Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia; (2) Institute for Clinical Medicine, Sechenov University, Moscow, Russia

12:20 - 12:30

A-0027 Living Together, Loving Apart: Health, Sexuality and Relationships in Middle-Aged and Older Men in Europe
Clotilde Sparano (1), Giammarco Alderotti (2), Giulia Rastrelli (3), Giovanni Corona (4), Linda Vignozzi (3), Leen Antonio (5), Freijo Felipe Casanueva (6), Aleksander Giwercman (7), Thang S Han (8), Ilpo T. Huhtaniemi (9), Chiara Lucchi (1), Terence O'neill (10), Jolanta Słowikowska-Hilczer (11), Jos Tournoy (12), Dirk Vanderschueren (5), Frederick Wu (13), Daniele Vignoli (2), Mario Maggi (1)
(1) Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence Italy; (2) Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy; (3) Andrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, Florence, Italy; (4) Endocrinology Unit, Azienda AUSL, Maggiore Hospital, Bologna, Italy; (5) Department of Chronic Diseases and Metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium, Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium; (6) Department of Medicine, CIBER de Fisiopatologıa Obesidad y Nutricion, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS) Santiago de Compostela, Spain; (7) Department of Translational Medicine, Lund University, Malmö, Sweden; (8) Institute of Cardiovascular Research, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK, Department of Endocrinology, Ashford and St Peter’s NHS Foundation Trust, Guildford Road, Chertsey, Surrey KT16 0PZ, UK; (9) Department of Metabolism, Digestion and Reproduction, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK; (10) NIHR Manchester Biomedical Research Centre, Manchester Academic Health Sciences Centre, Manchester University Foundation NHS Trust, Manchester, United Kingdom; (11) Department of Andrology and Reproductive Endocrinology, Medical University of Łódź, Łódź, Poland; (12) Department of Geriatrics, University Hospitals Leuven, and Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium; (13) Department of Endocrinology, Manchester University NHS Foundation Trust, Manchester, UK

12:30 - 13:00

A-0168 Ion channels in human sperm - a tale of unexplained male infertility and contraception
Timo Strünker
Germany